Cisplatin induced nephrotoxicity mechanism
WebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and … Webrotection against gentamicin-induced nephrotoxicity in rats (Sandhya et al. 1995). Interestingly, the dose of an antioxi-dant lipoic acid (0.12–0.48 mmole/kg) required to …
Cisplatin induced nephrotoxicity mechanism
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WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … WebNov 7, 2024 · In accordance with the above outlined mechanisms, ... (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine 22, 528–535 ...
WebNov 14, 2024 · The clinical application of cisplatin is limited by its adverse events, of which nephrotoxicity is the most commonly observed. In a cisplatin-induced pathological response, oxidative stress is one of the upstream reactions which inflicts different degrees of damages to the intracellular material components. Reactive oxygen species (ROS) are … WebMar 13, 2024 · Background: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the …
WebOct 22, 2024 · Cisplatin is a commonly used anticancer drug, but nephrotoxicity is a dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of... WebThe mechanisms of cisplatin-induced nephrotoxicity are complex and involve multiple pathways and molecules ( Figure 1) [ 92, 93 ]. The cellular pathways of cisplatin injury …
WebMar 9, 2024 · The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA damage, oxidative stress, and inflammation, which work together to aggravate AKI induced by cisplatin.
WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … dataverse for teams image columnWebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … bittle fab warrior alWebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly identified form of non-apoptotic regulated cell death induced by iron-mediated lipid peroxidation and is involved in the pathophysiology of various diseases. In this study, we … dataverse for teams rolesWebDec 16, 2024 · Introduction. Cisplatin is commonly applied in the treatment of a diversity of solid tumors in medical practice due to its simple administration and great efficacy. 1 Cisplatin efficiency is proportionate to its dose. Nevertheless, cisplatin has a relatively limited safety margin and exhibits significant dose-limiting side effects, such as vomiting, … dataverse for teams primary keyWebSep 27, 2024 · Cisplatin induces cancer cell death by binding to the N7 reactive center of purine residues and causes irreversible DNA damage in cancer cells during division ( Dasari and Tchounwou, 2014 ), thus blocking cell division and promoting apoptosis. bittle githubWebOct 26, 2024 · Background . Cisplatin is a powerful chemotherapeutic drug mainly used in the treatment of solid tumors. Aggregation of the drug in renal proximal tubule cells causes nephrotoxicity and renal failure. Investigations showed nephrotoxicity as Cisplatin’s dose-limiting side effect. One of the Cisplatin toxicity mechanisms is generation of … dataverse for teams share appWebSep 15, 2008 · Certain drugs are inherently nephrotoxic and include aminoglycosides, amphotericin B, cisplatin, contrast dye, and cyclosporine. 7, 34 For others, such as those associated with chronic ... dataverse for teams power apps