Foxm1 rfc
WebMar 21, 2024 · FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Protein C Deficiency. Among its … WebFeb 9, 2024 · We showed that RFC5 expression is positively correlated with FoxM1 expression in human glioma cells and FoxM1 is able to transcriptionally activate RFC expression by interaction with the RFC5 promoter. Furthermore, knockdown of FoxM1 or RFC5 partially re-sensitizes glioma cells to TMZ.
Foxm1 rfc
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WebJul 14, 2024 · FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has proven to be... WebNov 1, 2014 · FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance. FOXM1 is a potent oncogenic factor essential for cancer …
WebJun 30, 2011 · The FoxM1 transcription factor gene is overexpressed in cancer. Its expression is stimulated by oncogenic signaling pathways and reactive oxygen species. … WebMar 10, 2013 · Abstract. FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in quiescent or differentiated cells, but its level is highly elevated in proliferating and malignant cells. Overexpression of FOXM1 has been reported in more …
WebMay 5, 2024 · FOXM1 induction improves organismal fitness and extends the lifespan of progeroid mice Once the global improvement of cellular aging by transgene cyclic induction in fibroblasts from progeroid... WebFeb 9, 2024 · We showed that RFC5 expression is positively correlated with FoxM1 expression in human glioma cells and FoxM1 is able to transcriptionally activate RFC …
WebMay 7, 2024 · Forkhead box M1 (FOXM1) is a transcription factor best recognized as a master regulator of cell cycle progression on the basis of studies in a variety of cell types, including epithelial cells, T cells, B cells, and dendritic cells ( 4, 5 ). Among its isoforms, FOXM1b (heretofore designated simply FOXM1) has been studied most extensively and …
WebFOXM1. Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. [5] [6] The protein encoded by this gene is a member of the FOX family of transcription factors. [5] [7] Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year. [8] aratiatia damWebS. Gygi, Y. Rochon, B. Franza, 1999, Molecular and Cellular Biology. The impact of microRNAs on protein output bake ramaWebFeb 9, 2024 · FoxM1 regulates RFC5 expression through interaction with RFC5 promoter Using GeneQuest (Lasergene 7.1), we identified two potential FoxM1-binding motifs, i.e., 5′-GTTTGT-3′ and 5′-CAAATA-3′ … baker aluminum bradentonWebFeb 9, 2009 · FoxM1 is a member of the Forkhead family of transcription factors and is implicated in inducing cell proliferation and some forms of tumorigenesis. It binds promoter regions with a preference for tandem … baker alumniWebMay 28, 2024 · The FoxM1 NRD inhibits transcription factor transactivation activity early in the cell cycle. Transcription reporter assays suggest that the NRD negatively regulates the TAD through a sequestration mechanism (Park et al., 2008b; Wierstra and Alves, 2006a).To confirm a direct interdomain association and to define more precisely the NRD and TAD … baker aluminum lakeland flWebJun 11, 2024 · The relapse-free survival rate tended to be lower in PDAC cases with the expression of both DKK1 and FOXM1 compared to other cases (cases positive for either DKK1 or FOXM1 alone or negative for ... aratidWebMar 5, 2013 · FoxM1 is a member of the forkhead family of transcription factors. Since its identification 15 year ago, numerous studies have progressively contributed to our current understanding on FoxM1 functions. Early work showed that FoxM1 regulates the transcriptional program of the G2 phase of the cell cycle, and is essential for proper … arati barnet