Phosphodegron是什么意思
http://genesdev.cshlp.org/lookup/doi/10.1101/gad.1843810 http://genesdev.cshlp.org/lookup/doi/10.1101/gad.1843810
Phosphodegron是什么意思
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Webphosphodegron (pl. phosphodegrons) A phosphorylated degron; Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to … WebDec 16, 2024 · phosphodegron that recruits an E3 ubiquitin ligase, beta-transducin repeat-62 . containing homologue protein (β-TrCP) [11, 28]. β-TrCP is a substrate recognition . 63 . subunit of the Skp1-Cullin-F-box (SCF) complex that catalyzes formation of a . 64 . polyubiquitin chain on a substrate targeted for proteasomal degradation. The . 65
WebJan 28, 2024 · Here, we identify a second Fbw7 phosphodegron at Myc T244 that is required for Myc ubiquitylation and acts in concert with T58 to engage Fbw7. While Ras-dependent … WebJun 27, 2010 · Structural rearrangement of key phosphodegron-binding residues—including Tyr574 and Leu634, which form the hydrophobic binding site for residues such as leucine at position −2 in the ...
WebBiochemical verification revealed a mechanism by which SCF FBXO22 recognizes the motif XXPpSPXPXX as a conserved phosphodegron to target substrates for destruction. We … WebJul 7, 2012 · TAZ contains another phosphodegron in its N-terminal region that also matches the β-TrCP recognition sequence DSGXXS and is adjacent to the LATS phosphorylation site Ser-66 (Fig. 3 B). Phosphorylation of Ser-66 by LATS could provide the priming phosphorylation for subsequent phosphorylation of Ser-62 and Ser-58 by GSK3β …
WebThe phosphorylated phosphodegron then recruits the SCF β-TRCP E3 ubiquitin ligase, which catalyzes YAP ubiquitination, ultimately leading to YAP degradation. The phosphodegron …
WebAug 13, 2008 · Phosphodegron recognition by SCF Cdc4. F-box proteins (FBPs) are the substrate-specificity subunits of the multisubunit SCF family of E3 ligases, which contains … mountain chains of the worldWebThe phosphodegron is a short linear motif that is inert until phosphorylated, but upon phosphorylation generates a binding surface that interacts with a ubiquitin ligase. The main ubiquitin li-gase that recogises phosphodegrons in the cell cycle is the SCF [7,8]. The SCF is a multisubunit complex that consists of a core hear and listenWebRecognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase* Received for publication, August 11, 2004, and in revised form, September 9, 2004 … mountain chalet hotels twizelWeb23rd May, 2014. Ralf Max Leonhardt. Boehringer Ingelheim. No, it does not always work, but it often works (, and if it works, it is probably going to make your referee happy). I believe it is ... hear aramaicWebJul 12, 2024 · 通常而言,SCF通过识别底物蛋白上被磷酸化修饰后的特定结构域(也称作磷酸化降解结构域,“phosphodegron”),从而泛素化底物后进行降解。 mountain chalet north dakotaWebligase;phosphodegron Introduction Cellular duplication and differentiation requires me-chanisms that integrate cellular growth, genomic repli-cation,andequalnucleardivision.Misregulationofany hear aroundWebA General sequence alignment of SOX9 Cdc4 phosphodegron (CPD) motif against other high-affinity motifs present in previously established FBW7a substrates including cyclin E, cMYC, and c-Jun. B Immunoblot analysis of the immunoprecipitated HA-SOX9 or FLAG-FBW7a and their pull-down products. Western blots from whole-cell extract (WCE) of the mountain chalet redbook green