Stc1 mitochondria

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August undefined, 2024

WebMay 20, 2024 · We also demonstrated a previously unrecognized role for mitochondrial-associated STC1, via TLR4, in maintaining normal glycolysis, mitochondrial bioenergetics, … WebFeb 1, 2010 · As to targeting of STC1 to the mitochondria, two models have been proposed by Sazonova et al. : one model envisions the membrane receptor acting first as a signal …

Interactions between leucines within the signal peptides …

Webc Write a balanced chemical equation for the reaction within the mitochondria of. 0. c Write a balanced chemical equation for the reaction within the mitochondria of. document. 63. MGT 205 Unit 2 Discussion.doc. 0. MGT 205 Unit 2 Discussion.doc. 1. Midterm Exam 9_30.docx. 0. Midterm Exam 9_30.docx. 6 #4.pdf. 0 WebJun 22, 2024 · Stanniocalcin‑1 (STC1), a multifunctional glycoprotein with antioxidant and anti‑inflammatory properties, serves an important role in kidney protection. STC1 is one of the few hormones targeted to the mitochondria to regulate mitochondrial quality control by suppressing oxidative stress and mitochondrial damage. However, the mechanisms … ara rae

The respiratory effects of stanniocalcin-1 (STC-1) on intact ...

WebJan 15, 2024 · Mitochondria Cell metabolism Porcine 1. Introduction Stanniocalcin (STC-1) is an important hormone that was first found in the fish and is involved in the regulation of … Mammalian stanniocalcins are secreted phosphoglycoproteins1, and published work from our lab shows extracellularly applied STC1 is targeted to the mitochondria in WT C2C12 cells12; but fails to reach the mitochondria in Lrp2 KO C2C12 cells12. ExPASy-PROSITE analysis of STC1 protein predicts no mitochondrial … See more The open reading frame for human megalin mRNA encodes 4612 aa16. The primary structure of megalin predicts a type I transmembrane protein containing … See more The extracellular region of megalin contains 3 types of cysteine-rich repeat motifs: 36 ligand-binding motifs (class A), 1 EGF motif (class B.1), and 15 growth factor … See more To determine STC1 domains that interact with megalin, we co-expressed in HEK293T cells, full-length hLRP2/megalin (C-terminus FLAG-tagged) with full-length … See more WebJan 1, 2024 · STC1 is a mitochondrial intracrine molecule (defined as an extracellular signaling molecule that enters cells, translocates to mitochondria and alters their function). STC1 activates AMPK, which in turn upregulates uncoupling proteins (UCPs) and SIRT3, promoting mitochondrial anti-oxidant defenses. araragi abs

A glomerular transcriptomic landscape of - medRxiv

Effects of porcine STC-1 on cell metabolism and …

WebConfocal deconvolution immunofluorescence studies reveal co-localization of Mito-red (mitochondrial marker) with native Lrp2 (a), Stc1 (b) and Sirt3 (c) in C2C12 cells (similar results are... Webmitochondria where STC1 regulates superoxide generation (Oh-kouchi et al., 2012; Wang et al., 2009). Despite this, Stc1-deﬁ-cient mice do not show an obvious phenotype, suggesting ... Stc1 / BVE mice was observed (Figure 2A), as well as increased lung weight (Figure 2B). Although the tumors in this bakbijbelWebAug 28, 2013 · The cardiotoxic effects of STC1 appears to be mediated via mitochondrial dysfunction as indicated by loss of mitochondrial membrane potential, ROS production and increased mitochondrial calcium levels. Collectively, this work identifies STC1 as a critical determinant of AL-LC cardiotoxicity. Introduction araragi2055

"WebApr 12, 2024 · Tumor STC1 is critical for intrinsic resistance to tumor immunity. Our aforementioned results ( Figures 1 and S1) suggest that murine MC38, B16-F10, and LLC … " - Stc1 mitochondria

Stc1 mitochondria

Stanniocalcin1 is a key mediator of amyloidogenic light ... - Springer

WebMar 31, 2024 · Then, it targets the inner mitochondrial membrane, and more than 90% of cellular STC1 immunoreactivity is in mitochondria . Evidences suggest that mammalian … WebJun 9, 2024 · Of note, mitochondrial Stc1 associates with mitochondrial megalin of various MW, from an approximate 600 kD to an approximate 100 kD, and while bands of similar size/migration are observed in all cells, …

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WebAssociation between native megalin/Lrp2, Stc1 and Sirt3 in whole cell (c) and mitochondrial (d) lysates of kidney, C2C12, Raw264.7 and HEK293T cells. Immunoprecipitation was carried out using... WebSep 22, 2015 · Introduction. The mammalian pro-survival protein STC1 is expressed in many tissues and organs including the kidneys [].It is released to the extracellular milieu [], and binds to a cell-surface protein [], followed by internalization and targeting to the inner mitochondrial membrane [4,5].It is defined as a paracrine/intracrine protein; i.e., …

WebApr 28, 2024 · The authors hypothesized that STC1 pretreatment results in a low level of mitophagy, which reflects the effect of STC1 on mitochondrial injury, according to the principle that mitophagy is initiated by mitochondrial injury. This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The only known molecular function of human Stanniocalcin-1 to date is a SUMO E3 ubiquitin ligase activity in the SUMOylation cycle. However, STC1 interacts with many proteins in the cytoplasm, mitochondria, endoplasmatic reticulum, and in dot-like fashion in the cell nucleus. The N-terminal region of STC1 is the function …

WebFeb 20, 2024 · We discovered (1) increased expression of APOL1 in HR and nine other significant differentially expressed genes, including stanniocalcin (STC1), which has a role in mitochondrial and calcium-related processes, (2) differential correlations between HR and LR APOL1 and metabolism pathway genes, but similar correlations with extracellular … WebJun 22, 2024 · Stanniocalcin‑1 (STC1), a multifunctional glycoprotein with antioxidant and anti‑inflammatory properties, serves an important role in kidney protection. STC1 is one of …

WebJul 7, 2024 · The studies shed light on how STC1 regulates mitochondrial metabolism. In this study, we used the TriCEPS-based ligand–receptor methodology to identify putative …

Webof STC1 to mitochondria is dependent on LRP2/megalin binding (Li et al, 2024, 2024). The studies shed light on how STC1 regulates mitochondrial metabolism. In this study, we used the TriCEPS-based Department of Biology, Croucher Institute for Environmental Sciences, Hong Kong Baptist University, Hong Kong SAR, China Correspondence: ckcwong@hkbu ... ararageWebThe mammalian homolog of the fish calcium regulatory hormone stanniocalcin-1 (STC1) is ubiquitously expressed and likely functions in an autocrine/paracrine fashion. Mammalian … bakb jpWebMay 19, 2024 · A mitochondrial membrane potential analysis showed that the red-green fluorescence ratio in the CON and SCON groups was 3.15 ± 0.13% and 2.57 ± 0.1%, … araragi ageWebApr 7, 2024 · Stanniocalcin 1 (STC1) plays an integral role in ovarian cancer (OC). However, the functional role of STC1 in metastasis, lipid metabolism and cisplatin (DDP) chemoresistance in OC is not fully understood. Methods Single-cell sequencing and IHC analysis were performed to reveal STC1 expression profiles in patient tissues. bak bildungszentrum landauWebJul 7, 2024 · The studies shed light on how STC1 regulates mitochondrial metabolism. In this study, we used the TriCEPS-based ligand–receptor methodology to identify putative STC1-binding proteins/receptors in human cells, followed by surface plasmon resonance (SPR) analysis to characterize the binding and kinetic affinity. Results bakblik 20x20WebDec 7, 2015 · Studies from our lab suggest that mammalian STC1 upregulates uncoupling proteins and suppresses mitochondrial superoxide generation 8; and in doing so, it inhibits macrophage function 8 ... bak bildungsakademie kasselWebIn the mitochondria, megalin exists in association with stanniocalcin-1 (Stc1) and Sirt3. ... Megalin-Mediated Trafficking of Mitochondrial Intracrines: Relevance to Signaling and … bak blake