The pregnane x receptor

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August undefined, 2024

WebbRecent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of phase I and phase II drug-metabolizing enzymes, … WebbPregnane X receptor Function . PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by... Ligands . PXR is activated by a …

9612 - Gene ResultNCOR2 nuclear receptor corepressor 2 [ (human)]

Webb2006 Orphan nuclear receptor pregnane X receptor sen-sitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 20:279–290 24. Curnow KM, … Webb24 sep. 2024 · The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role … slow cooker loin chops

A Role for the Pregnane X Receptor in High-Density Lipoprotein ...

プレグナンX受容体（プレグナンXじゅようたい、英: pregnane X receptor、略称: PXR）は、ヒトではNR1I2遺伝子によってコードされるタンパク質である。SXR（steroid and xenobiotic sensing nuclear receptor）、NR1I2（nuclear receptor subfamily 1, group I, member 2）の名称でも知られる。 Webb29 sep. 2024 · The pregnane X receptor (PXR, NR1I2) is a ligand-activated transcription factor and a member of the nuclear receptor (NR) superfamily [].As part of the … Webb13 juni 2000 · We and others recently described a new member of the steroid/thyroid hormone receptor family, termed the pregnane X receptor (PXR), that serves as a key … slow cooker liver bacon and onions

Pregnane X Receptor - an overview ScienceDirect Topics

Regulation of mRNA Expression of Xenobiotic Transporters by the ...

Webb1 juli 2005 · THE PREGNANE X RECEPTOR (PXR; NR1I2), a member of the nuclear hormone receptor (NR) superfamily, is a key regulator of bile salt, steroid hormone, and xenobiotic … WebbThe pregnane X receptor (PXR) is a xenobiotic nuclear receptor that is also sensitive to bile acids as ligands.10,11 A study in this issue of Arteriosclerosis, Thrombosis, and … slow cooker loin of porkWebbBackground: The pregnane X receptor (PXR) is a nuclear receptor (NR) involved in the detoxification of xenobiotic compounds via upregulation of cytochrome P450 enzyme … slow cooker loaded potatoes

"Webb19 jan. 2024 · The pregnane X receptor (PXR) is implicated in fatty liver, vitamin D homeostasis, bile acids homeostasis, steroid hormones homeostasis and inflammatory … " - The pregnane x receptor

The pregnane x receptor

Identification of new human pregnane X receptor ligands among ...

Webb20 apr. 2024 · The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial … Webb21 jan. 2024 · 孕烷X受体. 孕烷X受体(pregnane X receptor,PXR)是核受体超家族成员之一。其主要功能是感知外来有毒物质的存在，并相应地上调参与解毒和清除这些物质的蛋白 …

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WebbEl receptor X de pregnano (PXR), también conocido como NR1I2 (de sus siglas en inglés "nuclear receptor subfamily 1, group I, ... MeSH: pregnane+X+receptor (en inglés) Datos: … WebbThe pregnane X receptor (PXR) is a promiscuous nuclear receptor that has evolved to protect the body from toxic chemicals. PXR is activated by a structurally diverse …

WebbBackground: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved … WebbThe Pregnane X Receptor. Pregnane X receptor (NR1I2) is a broad-specificity sensor playing a critical role in the regulation of phase I oxidative enzymes, phase II conjugating …

Webb30 juni 2024 · Pregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is … WebbFarnesoid X receptor (FXR), a member of the nuclear receptor superfamily that is mainly expressed in enterohepatic tissues, has been discovered as a crucial regulator for balancing liver inflammatory processes and metabolism [ 5, 6, 7] and thus has become a pharmacological target for liver disorders.

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WebbPregnane X Receptor (PXR) belongs to the nuclear receptors’ superfamily and mainly functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed in normal and malignant tissues. Drug metabolizing enzymes and transporters are also under PXR’s regulation. Antineoplastic agents are of particular interest since cancer … slow cooker loin of pork recipesWebbMicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor Jiaqi Li,1,2 Jing Zhao,2 Huan Wang,2 Xiaohan Li,2 … slow cooker london broil balsamicWebbPXR is remarkably divergent between species, with the rabbit, rat, and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains. … slow cooker london broil food networkWebb15 okt. 2024 · Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is … slow cooker london broil and gravyWebbAbstract Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear … slow cooker london broil recipe with red wineWebb1 juli 2024 · The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including … slow cooker london broil meatWebbWe studied in mice and human adenocarcinoma-derived Caco-2 cells the impact of low calcium on markers of inflammation (cyclooxygenase-2; COX-2), of detoxification (pregnane and xenobiotic receptor (PXR)/steroid and xenobiotic receptor (SXR), … slow cooker london broil beer